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Camptothecin
【Botanical】:Camptotheca acuminata Decne
【Appearance】: Light Yellow powder.
【Specification】98% by HPLC
【Molecular Formula】: C20H16N2O4
【Molecular Weight】: 348.36
【CAS Number】: 7689-03-4
【Actions】: Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death. In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death. Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility. At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.
Baoji Herbest Co., Ltd as a leading manufacture of herbal extracts in China. specialized in the provision of high-purity pharmaceutical ingredient separation and purification technological solutions.
We supply
Chlorogenic acid 98%.cryptochlorogenic acid; neochlorogenic acid; Isochlorogenic acid
Hesperidin 98%
Andrographolide
Daidzein
Resveratol
Tanshinone IIA
Puerarin 99%
Hypericin
Rutin 98%
Sodium Aescinate
Paeoniflorm
Tetrahydropalmatine
GinkgolideA;B;C
Gardenoside
Ginsenoside Rb1;Rb2;Rb3,Rg1,Rg2,Rg3;Rh1;Rh2;Rh3;Rf,Rf11;Rc;Re;Rd
SaikosaponinA;C;D
Costundide; Dehydrocostus Lactone.
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